Assessment Tools

RIFM developed a number of Assessment Tools and Methodologies to improve or aid the safety evaluation of fragrance materials. Almost all are available to RIFM Database subscribers in the Tools and Models section of the Database. The TDSE and SAM tools are available to all RIFM Members from the Member section of this web site (login to the RIFM Member Area required).

The Creme/RIFM Aggregate Exposure Model - A standard approach that can be widely used by the fragrance industry for total systemic exposure.

Toxicology Data Search Engine (TDSE) Web Application - By inputting one or more CAS numbers, the TDSE simultaneously searches the nine most commonly used toxicological databases, collates the results, and generates a combined accesible output.

Skin Absorption Model (SAM) - An in silico, skin absorption model developed and tailored specifically for fragrance ingredients. SAM is used to estimate the percentage of skin absorption from a fragrance ingredient.  Read more about SAM in Food and Chemical Toxicology 74 (2014) 164-176.

From the RIFM Database (RIFM Database subscription needed)
​The 2-Box Air Dispersion Model - Uses room within a room technology to calculate peak air concentrations from 3 product categories, Aerosol Air Fresheners, Candles/Incense and Plug-In Air Fresheners/Reed Diffusers. This model will establish inhalation Toxicological Threshold of Concern (TTC).

The Multiple Path Particle Dosimetry (MPPD) Inhalation Exposure Model - Predicts deposition patterns in the airway and determines the deposited dose. Based on knowledge of the cell types in the regions of greatest deposition, the computational model will allow for the prediction of potential physiological effects.