RIFM Staff Co-Author Top Cited Human Health Publications



Dr. Anne Marie Api, RIFM Vice President of Human Health Science, and Dr. Valerie Politano, Senior Human Health Scientist, are among the co-authors of three publications on contact sensitization that are listed at 8 and 9 of the top 20 most cited articles published in the journal Dermatitis.


  1. Quantitative risk assessment of contact sensitization: clinical data to assess utility of the model. Marie Api A, Belsito D, Bickers D, Bruze M, Calow P, Greim H, Hanifin JM, McNamee PM, Rogers AE, Saurat JH, Sipes IG, Tagami H. Dermatitis; 2010 Jul-Aug;21(4):207-13.
  2. Does the new standard for eugenol designed to protect against contact sensitization protect those sensitized from elicitation of the reaction? Svedman C, Engfeldt M, Api AM, Politano VT, Belsito DV, Gruvberger B, Bruze M. Dermatitis; 2012 Jan-Feb;23(1):32-8.

Dr. Anne Marie Api and Dr. Jon Lalko, Human Health Scientist, are among the co-authors for the top cited publications in the journal Regulatory Toxicology and Pharmacology.


  1. Api AM, Basketter DA, Cadby PA, Cano MF, Ellis G, Gerberick GF, Griem P, McNamee PM, Ryan CA, Safford R: Dermal sensitization quantitative risk assessment (QRA) for fragrance ingredients. Regul Toxicol Pharmacol; 2008 Oct;52(1):3-23
  2. Api AM, Vey M: Implementation of the dermal sensitization Quantitative Risk Assessment (QRA) for fragrance ingredients. Regul Toxicol Pharmacol; 2008 Oct;52(1):53-61
  3. Lalko J, Api AM: Citral: identifying a threshold for induction of dermal sensitization. Regul Toxicol Pharmacol; 2008 Oct;52(1):62-73

Dr. Anne Marie Api also appears as co-author for one of the top cited publications in the journal Cellular Molecular Life Science. It appears in the seventh spot of their top 20.


  1. Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods and regulatory aspects. Current knowledge assembled at an international workshop at BfR, Germany. Peiser M, Tralau T, Heidler J, Api AM, Arts JH, Basketter DA, English J, Diepgen TL, Fuhlbrigge RC, Gaspari AA, Johansen JD, Karlberg AT, Kimber I, Lepoittevin JP, Liebsch M, Maibach HI, Martin SF, Merk HF, Platzek T, Rustemeyer T, Schnuch A, Vandebriel RJ, White IR, Luch A. Cell Mol Life Sci; 2012 Mar;69(5):763-81.

The goal of RIFM's Human Health Science Program is to reduce fragrance allergy. To achieve that goal, the Quantitative Risk Assessment (QRA) was developed to take into consideration conditions of use when setting appropriate fragrance ingredient levels in consumer products.

RIFM's progressive Human Health Science program continues to develop methodologies for the fragrance industry especially in Alternative models. Currently with Creme, an industry data modeling company, RIFM's Human Health scientists are refining an Aggregate Exposure Model for Fragrance Materials.