The objective of the Respiratory Sciences Program at RIFM is to understand the physiological effects of exposure to fragrance materials upon inhalation from a consumer product, when that product is used as intended. The research program identifies 5 important steps, moving from exposure to clinical response. The 5 steps are addressed by a series of studies designed to feed data into each other such that a complete picture can be assembled regarding the impact of exposure on bioavailability, the effect of bioavailability on protein reactivity, subsequent immune system stimulation, and finally, the potential clinical outcome resulting from the exposure event.

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RIFM Respiratory Bulletin
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Posters

	Clinical Exposure Study to a Surrogate Air Freshener Product
	Modeling Vapor Uptake and Tissue Disposition in Human Lungs
	Reactivity Profile of Contact and Respiratory Low Molecular Weight Allergens in a Competitive Peptide Reactivity Assay

Publications

	Derivation of Mass Transfer Coefficients for Transient Uptake and Tissue Disposition of Soluble and Reactive Vapors in Lung Airways
	Evaluating Inhalation Safety of Fragrances
	Fragranced Products and VOCs
	Journal of Aerosol Science: Computational Fluid Dynamics Simulations of Submicrometer and Micrometer Particle Deposition in the Nasal Passages of a Sprague-Dawley Rat
	RIFM 2010 Annual Report