The objective of the Respiratory Sciences Program at RIFM is to understand the physiological effects of exposure to fragrance materials upon inhalation from a consumer product, when that product is used as intended. The research program identifies 5 important steps, moving from exposure to clinical response. The 5 steps are addressed by a series of studies designed to feed data into each other such that a complete picture can be assembled regarding the impact of exposure on bioavailability, the effect of bioavailability on protein reactivity, subsequent immune system stimulation, and finally, the potential clinical outcome resulting from the exposure event.
RIFM Respiratory Bulletin
|Clinical Exposure Study to a Surrogate Air Freshener Product|
|Modeling Vapor Uptake and Tissue Disposition in Human Lungs|